If and when a photograph is taken of US Vice President JD Vance standing next to Iran's Parliamentary Speaker Mohammad Bagher Ghalibaf in Islamabad this weekend, it will make history.

That moment would mark the highest-level face-to-face talks between the Islamic Republic of Iran and the United States of America since the 1979 Islamic Revolution shattered their strong strategic bond and cast a long shadow which still darkens relations to this day.

The two men may not smile. They may not even shake hands. It would not make this troubled relationship any more easy, any less hostile.

But it would send a signal that both sides want to try to end a war sending shocks worldwide, avoid an even riskier escalation, and turn to diplomacy to do a deal.

There's zero chance of President Trump's optimistic prediction of a peace deal within this shaky two-week ceasefire; its terms have been contested and broken since the moment it was announced earlier this week.

Even until the eleventh hour, Iranians kept everyone guessing over whether they would still show up while Israel insisted there would be no ceasefire in Lebanon.

However, if serious and sustained talks make a start, it would also represent the most significant push since Trump pulled out of the previous landmark nuclear deal in 2018, during his first term, which he labeled as the worst deal in history.

Efforts since then, including during President Biden's term, have made little headway. However, the dispatch of more senior officials and the high stakes of failure for all sides could open possibilities that weren't there before. But experts warn that the current scenario is exponentially harder.

The gaps between the two sides remain wide; the distrust runs deep. Notably, Tehran's last two rounds of negotiations were upended by the onset of intensified conflict. Currently, their negotiating styles are poles apart, posing additional challenges.

The moment of truth could be approaching for all sides, with stark reminders of past negotiations shaping the context for these ground-breaking discussions.