Kennedy, the son of Robert F. Kennedy and the nephew of President John F. Kennedy, has transitioned from environmental law to vocal critiques of the US healthcare system, particularly focusing on vaccines and food safety. Despite Democrats expressing concerns over his past comments—especially those questioning vaccine safety—Kennedy has stated he is not anti-vaccine but advocates for enhanced safety protocols. Senator Bernie Sanders scrutinized Kennedy during the hearing, sharing visuals of anti-vaccine merchandise sold by Kennedy's former organization but noted his "Make America Healthy Again" campaign slogan. Despite these challenges, Kennedy secured the support of Senator Bill Cassidy, a notable physician and previously skeptical Republican, which bodes well for his confirmation.

As health secretary, Kennedy would oversee pivotal agencies like the CDC, FDA, and NIH, suggesting a transformative agenda for US food and healthcare policies, without outright bans on vaccines or fast food. His confirmation remains contingent on full Senate approval, in which Republicans hold a slight majority.