US news anchor Savannah Guthrie and her family have released a new video pleading for the safe return of their mother.

We received your message, and we understand, Guthrie said in the video posted to Instagram on Saturday evening, flanked by her two siblings. We beg you now to return our mother to us so that we can celebrate with her.

This is the only way we will have peace, she continued. This is very valuable to us - and we will pay. Her video did not provide any details about the message she referenced.

Nancy Guthrie disappeared in the middle of the night from her home in Tucson, Arizona, last weekend. Authorities believe she was taken against her will.

On Sunday, the sheriff's office said in a post on social media that no suspects, persons of interest, or vehicles had been identified in the case.

The FBI is offering a $50,000 reward for information.

Nancy Guthrie was discovered missing when she did not attend a Sunday church service on February 1, and other members grew concerned.

Authorities say that early on Sunday morning, a doorbell camera in her home was disconnected and removed. At about 02:28 local time, the app connected to her pacemaker, an implanted cardiac device, was also disconnected from her phone.

The FBI is investigating a potential ransom note sent to several media outlets.

Reportedly seeking millions in cryptocurrency, the kidnappers demanded an undisclosed amount for Nancy Guthrie's safe return. The family has released previous videos stating their willingness to communicate with the alleged abductors.

Public officials, including Pima County Sheriff Chris Nanos, have confirmed that inquiries are ongoing, with the assumption that Nancy is still alive.

Guthrie, recognized for her role on NBC's Today show and her contributions as a chief legal correspondent, has expressed deep concern over her mother's health, highlighting the urgency for medication that Nancy needs daily.