The film beat the previous record of 14 nominations and emerged ahead of its nearest rival this year, Leonardo DiCaprio's thriller One Battle After Another, which is up for 13 awards.
Sinners' contenders include its star Michael B Jordan and his British co-stars Wunmi Mosaku and Delroy Lindo.
Other notable nominees include Timothée Chalamet, who is hoping to win his first Oscar after two previous nominations, and Irish actress Jessie Buckley, who is the frontrunner to win best actress for Hamnet.
However, fans were surprised to see notable omissions, such as Paul Mescal for Hamnet, and the cast of Wicked: For Good.
The awards will take place on March 15 in Hollywood.
The leading films:
- Sinners - 16
- One Battle After Another - 13
- Marty Supreme - 9
- Frankenstein - 9
- Sentimental Value - 9
- Hamnet - 8
Sinners has exceeded expectations and challenged the perception that horror films often struggle at award shows. The film showcases Michael B Jordan in a dual role as twin brothers setting up a juke joint in Mississippi in the 1930s, only to face off against vampires. Critics describe it as 'more than just a horror film', infused with themes of music, race, and redemption.
BBC Radio 1 critic Ali Plumb noted its broad acclaim, while culture editor Katie Razzall applauded its unique blend of genres.
Alongside Sinners, One Battle After Another offers a political commentary relevant to today's climate, featuring DiCaprio as a revolutionary.
Chalamet aims for first Oscar
This year's best actor category is highly competitive, including Chalamet for Marty Supreme. Emma Stone also stands out with her seventh nomination for Bugonia. The animated hit KPop Demon Hunters is eyeing wins in best animated feature and best song.
The nominees' announcement has set the stage for an exciting awards season ahead.
